Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia
Identifieur interne : 001D18 ( Main/Exploration ); précédent : 001D17; suivant : 001D19Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia
Auteurs : Mustafa Saad ; Ali S. Omrani ; Kamran Baig ; Abdelkarim Bahloul ; Fatehi Elzein ; Mohammad Abdul Matin ; Mohei A. A. Selim ; Mohammed Al Mutairi ; Daifullah Al Nakhli ; Amal Y. Al Aidaroos ; Nisreen Al Sherbeeni ; Hesham I. Al-Khashan ; Ziad A. Memish ; Ali M. AlbarrakSource :
- International Journal of Infectious Diseases [ 1201-9712 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Infections à coronavirus.
- mortalité : Infections à coronavirus.
- épidémiologie : Arabie saoudite, Infections à coronavirus.
- Adulte d'âge moyen, Coronavirus du syndrome respiratoire du Moyen-Orient, Femelle, Humains, Mâle, Sujet âgé, Études rétrospectives.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Saudi Arabia.
- mortality : Coronavirus Infections.
- Aged, Female, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus, Retrospective Studies.
Abstract
To report the experience with Middle East respiratory syndrome coronavirus (MERS-CoV) infection at a single center in Saudi Arabia.
Cases of laboratory-confirmed MERS-CoV occurring from October 1, 2012 to May 31, 2014 were reviewed retrospectively. Information sources included medical files, infection control outbreak investigations, and the preventive medicine database of MERS-CoV-infected patients. Data were collected on clinical and epidemiological aspects and outcomes.
Seventy consecutive patients were included. Patients were mostly of older age (median 62 years), male (46, 65.7%), and had healthcare acquisition of infection (39, 55.7%). Fever (43, 61.4%), dyspnea (42, 60%), and cough (38, 54.3%) were the most common symptoms. The majority developed pneumonia (63, 90%) and required intensive care (49, 70%). Infection commonly occurred in clusters. Independent risk factors for severe infection requiring intensive care included concomitant infections (odds ratio (OR) 14.13, 95% confidence interval (CI) 1.58–126.09;
MERS-CoV can cause severe infection requiring intensive care and has a high mortality. Concomitant infections and low albumin were found to be predictors of severe infection, while age ≥65 years was the only predictor of increased mortality.
Url:
DOI: 10.1016/j.ijid.2014.09.003
PubMed: 25303830
PubMed Central: 7110769
Affiliations:
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Al-Khashan</name><affiliation><nlm:aff id="aff0025">Department of Family and Community Medicine, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="aff0035">Ministry of Health & college of Medicine, Al-Faisal University, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Albarrak, Ali M" sort="Albarrak, Ali M" uniqKey="Albarrak A" first="Ali M." last="Albarrak">Ali M. Albarrak</name><affiliation><nlm:aff id="aff0005">Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25303830</idno><idno type="pmc">7110769</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110769</idno><idno type="RBID">PMC:7110769</idno><idno type="doi">10.1016/j.ijid.2014.09.003</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000D66</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D66</idno><idno type="wicri:Area/Pmc/Curation">000D66</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D66</idno><idno type="wicri:Area/Pmc/Checkpoint">001126</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001126</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:25303830</idno><idno type="wicri:Area/PubMed/Corpus">001817</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001817</idno><idno type="wicri:Area/PubMed/Curation">001817</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001817</idno><idno type="wicri:Area/PubMed/Checkpoint">001969</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001969</idno><idno type="wicri:Area/Ncbi/Merge">000F31</idno><idno type="wicri:Area/Ncbi/Curation">000F31</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F31</idno><idno type="wicri:doubleKey">1201-9712:2014:Saad M:clinical:aspects:and</idno><idno type="wicri:Area/Main/Merge">001D32</idno><idno type="wicri:Area/Main/Curation">001D18</idno><idno type="wicri:Area/Main/Exploration">001D18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia</title><author><name sortKey="Saad, Mustafa" sort="Saad, Mustafa" uniqKey="Saad M" first="Mustafa" last="Saad">Mustafa Saad</name><affiliation><nlm:aff id="aff0005">Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name><affiliation><nlm:aff id="aff0005">Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff0010">King Saud University, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Baig, Kamran" sort="Baig, Kamran" uniqKey="Baig K" first="Kamran" last="Baig">Kamran Baig</name><affiliation><nlm:aff id="aff0015">Department of Infection Prevention and Control, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Bahloul, Abdelkarim" sort="Bahloul, Abdelkarim" uniqKey="Bahloul A" first="Abdelkarim" last="Bahloul">Abdelkarim Bahloul</name><affiliation><nlm:aff id="aff0005">Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Elzein, Fatehi" sort="Elzein, Fatehi" uniqKey="Elzein F" first="Fatehi" last="Elzein">Fatehi Elzein</name><affiliation><nlm:aff id="aff0005">Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Matin, Mohammad Abdul" sort="Matin, Mohammad Abdul" uniqKey="Matin M" first="Mohammad Abdul" last="Matin">Mohammad Abdul Matin</name><affiliation><nlm:aff id="aff0020">Department of Medicine, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Selim, Mohei A A" sort="Selim, Mohei A A" uniqKey="Selim M" first="Mohei A. A." last="Selim">Mohei A. A. Selim</name><affiliation><nlm:aff id="aff0025">Department of Family and Community Medicine, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Mutairi, Mohammed Al" sort="Mutairi, Mohammed Al" uniqKey="Mutairi M" first="Mohammed Al" last="Mutairi">Mohammed Al Mutairi</name><affiliation><nlm:aff id="aff0030">Department of Radiology, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Nakhli, Daifullah Al" sort="Nakhli, Daifullah Al" uniqKey="Nakhli D" first="Daifullah Al" last="Nakhli">Daifullah Al Nakhli</name><affiliation><nlm:aff id="aff0005">Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff0015">Department of Infection Prevention and Control, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Aidaroos, Amal Y Al" sort="Aidaroos, Amal Y Al" uniqKey="Aidaroos A" first="Amal Y. Al" last="Aidaroos">Amal Y. Al Aidaroos</name><affiliation><nlm:aff id="aff0005">Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff0015">Department of Infection Prevention and Control, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Sherbeeni, Nisreen Al" sort="Sherbeeni, Nisreen Al" uniqKey="Sherbeeni N" first="Nisreen Al" last="Sherbeeni">Nisreen Al Sherbeeni</name><affiliation><nlm:aff id="aff0005">Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Al Khashan, Hesham I" sort="Al Khashan, Hesham I" uniqKey="Al Khashan H" first="Hesham I." last="Al-Khashan">Hesham I. Al-Khashan</name><affiliation><nlm:aff id="aff0025">Department of Family and Community Medicine, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="aff0035">Ministry of Health & college of Medicine, Al-Faisal University, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Albarrak, Ali M" sort="Albarrak, Ali M" uniqKey="Albarrak A" first="Ali M." last="Albarrak">Ali M. Albarrak</name><affiliation><nlm:aff id="aff0005">Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (mortality)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Retrospective Studies</term><term>Saudi Arabia (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arabie saoudite (épidémiologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mâle</term><term>Sujet âgé</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Arabie saoudite</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec><title>Objectives</title><p>To report the experience with Middle East respiratory syndrome coronavirus (MERS-CoV) infection at a single center in Saudi Arabia.</p></sec><sec><title>Methods</title><p>Cases of laboratory-confirmed MERS-CoV occurring from October 1, 2012 to May 31, 2014 were reviewed retrospectively. Information sources included medical files, infection control outbreak investigations, and the preventive medicine database of MERS-CoV-infected patients. Data were collected on clinical and epidemiological aspects and outcomes.</p></sec><sec><title>Results</title><p>Seventy consecutive patients were included. Patients were mostly of older age (median 62 years), male (46, 65.7%), and had healthcare acquisition of infection (39, 55.7%). Fever (43, 61.4%), dyspnea (42, 60%), and cough (38, 54.3%) were the most common symptoms. The majority developed pneumonia (63, 90%) and required intensive care (49, 70%). Infection commonly occurred in clusters. Independent risk factors for severe infection requiring intensive care included concomitant infections (odds ratio (OR) 14.13, 95% confidence interval (CI) 1.58–126.09; <italic>p</italic> = 0.018) and low albumin (OR 6.31, 95% CI 1.24–31.90; <italic>p</italic> = 0.026). Mortality was high (42, 60%), and age ≥65 years was associated with increased mortality (OR 4.39, 95% CI 2.13–9.05; <italic>p</italic> < 0.001).</p></sec><sec><title>Conclusions</title><p>MERS-CoV can cause severe infection requiring intensive care and has a high mortality. Concomitant infections and low albumin were found to be predictors of severe infection, while age ≥65 years was the only predictor of increased mortality.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. 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Albarrak</name><name sortKey="Bahloul, Abdelkarim" sort="Bahloul, Abdelkarim" uniqKey="Bahloul A" first="Abdelkarim" last="Bahloul">Abdelkarim Bahloul</name><name sortKey="Baig, Kamran" sort="Baig, Kamran" uniqKey="Baig K" first="Kamran" last="Baig">Kamran Baig</name><name sortKey="Elzein, Fatehi" sort="Elzein, Fatehi" uniqKey="Elzein F" first="Fatehi" last="Elzein">Fatehi Elzein</name><name sortKey="Matin, Mohammad Abdul" sort="Matin, Mohammad Abdul" uniqKey="Matin M" first="Mohammad Abdul" last="Matin">Mohammad Abdul Matin</name><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><name sortKey="Mutairi, Mohammed Al" sort="Mutairi, Mohammed Al" uniqKey="Mutairi M" first="Mohammed Al" last="Mutairi">Mohammed Al Mutairi</name><name sortKey="Nakhli, Daifullah Al" sort="Nakhli, Daifullah Al" uniqKey="Nakhli D" first="Daifullah Al" last="Nakhli">Daifullah Al Nakhli</name><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name><name sortKey="Saad, Mustafa" sort="Saad, Mustafa" uniqKey="Saad M" first="Mustafa" last="Saad">Mustafa Saad</name><name sortKey="Selim, Mohei A A" sort="Selim, Mohei A A" uniqKey="Selim M" first="Mohei A. A." last="Selim">Mohei A. A. Selim</name><name sortKey="Sherbeeni, Nisreen Al" sort="Sherbeeni, Nisreen Al" uniqKey="Sherbeeni N" first="Nisreen Al" last="Sherbeeni">Nisreen Al Sherbeeni</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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